Journal article
Enhanced wound healing properties of guar gum/curcumin-stabilized silver nanoparticle hydrogels
S Bhubhanil, C Talodthaisong, M Khongkow, K Namdee, P Wongchitrat, W Yingmema, JA Hutchison, S Lapmanee, S Kulchat
Scientific Reports | Published : 2021
Abstract
Biocompatible materials that act as scaffolds for regenerative medicine are of enormous interest. Hydrogel-nanoparticle composites have great potential in this regard, however evaluations of their wound healing and safety in vivo in animal studies are scarce. Here we demonstrate that a guar gum/curcumin-stabilized silver nanoparticle hydrogel composite is an injectable material with exceptional wound healing and antibacterial properties. We show that the curcumin-bound silver nanoparticles themselves exhibit low cytotoxicity and enhance proliferation, migration, and collagen production in in vitro studies of human dermal fibroblasts. We then show that the hydrogel-nanoparticle composite prom..
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Awarded by Australian Research Council
Funding Acknowledgements
The authors thank you Miss Siriwan Sriwong, Laboratory Animal Center, Thammasat University, for excellent technical assistance. We also would like to thank you the valuable comments from the Pathology Information and learning Center, Department of Pathobiology, Faculty of Science, Mahidol University for histological analysis. This work was supported by grants from the Faculty of Medicine (001/2562 to S. Lapmanee and 002/2563 to S. Bhubhanil), Research Promotion and Development, Siam University (003/02/2563 to S. Bhubhanil), Research and Graduate Studies, Khon Kaen University (S. Kulchat). MK and KN were supported by the target development group grant (Cosmeceuticals) P1952244, from the National Science and Technology Development Agency (NSTDA, Thailand) and would like to thank the National Nanotechnology center (NANOTEC), NSTDA, Thailand for facilities and publication support. JAH acknowledges support from Australian Research Council (ARC) Future Fellowship (FT180100295).